Use of nitriles as polar aprotic solvents

Details Use of nitriles as polar aprotic solvents Use of nitriles as polar aprotic solvents

C - Chemistry, Metallurgy

07

B

C07B 39/00 (2006.01) C07C 17/20 (2006.01) C07C 201/12 (2006.01) C07C 205/12 (2006.01)

Patent

CA 2376484

The invention concerns the use of aliphatic nitriles with relatively high molecular weight, as polar aprotic solvents, in particular in nucleophilic substitution reactions of the aromatic type. Said nitriles have a molecular mass more 79, preferably more than 90. The invention is useful for synthesis of fluorinated aromatic compounds.

La présente invention vise l'utilisation de nitriles aliphatiques de poids moléculaire relativement élevé, comme solvants aprotiques polaires, notamment dans des réactions de substitution nucléophile de type aromatique. Ces nitriles présentent une masse moléculaire supérieure à 79, de préférence supérieure à 90. Application à la synthèse de composés fluorés aromatiques.

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