A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/192 (2006.01)
Patent
CA 2583336
Compositions and methods for using nordihydroguaiaretic acid (NDGA) derivatives for preventing the expression of MDR-1 gene and the synthesis of PgP protein or reversing multiple drug resistance in cells, and for using NDGA derivatives in combination with additional chemotherapeutic agents to treat drug resistant cancer and infections.
L'invention concerne des compositions et des méthodes d'utilisation de dérivés d'acide nordihydroguaïarétique (NDGA) pour prévenir l'expression du gène MDR-1 et la synthèse de la protéine PgP ou lutter contre une résistance multiple aux médicaments dans des cellules, ainsi que des méthodes d'utilisation de dérivés de NDGA en association avec des agents chimiothérapeutiques additionnels pour traiter des cancers et des infections qui résistent aux médicaments.
Chang Chih-Chuan
Hsu Ming-Hua
Huang Ru Chih C.
Hwu Jih-Ru
Lee Yuan C.
Gowling Lafleur Henderson Llp
Johns Hopkins University
LandOfFree
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