Use of novel organoselenium compounds as pro-oxidizing...

C - Chemistry – Metallurgy – 07 – D

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C07D 293/10 (2006.01) A61K 31/395 (2006.01) A61K 31/58 (2006.01) C07D 293/12 (2006.01) C07J 43/00 (2006.01) C07J 51/00 (2006.01)

Patent

CA 2216334

The invention relates to novel organoselenium compounds. These compounds are represented by the following formula I: (see fig. I) in which: R1 to R5 can have various meanings of which alkyl, substituted or non-substituted aryl, and m is equal to 0 or 1, X is selected from (CR6R7)n in which n = 0 or 1, and CO. These compounds are active principles for the manufacture of anti-tumor drugs, especially with pro-oxidizing activity.

L'invention concerne des composés organosélénium nouveaux, représentés par la formule I suivante : (voir fig. I), dans laquelle R1 à R5 peuvent représenter différents groupements dont, notamment, un groupement alkyle, un groupement aryle substitué ou non substitué; m est égal à 0 ou à 1, et X est choisi entre (CR6R7)n, dans lequel n = 0 ou 1, et CO. Ces composés sont des principes actifs pour la fabrication de médicaments antinéoplastiques, ayant en particulier une activité pro-oxydante.

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