C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/7115 (2006.01) A61K 31/713 (2006.01) C07H 21/00 (2006.01) A61P 31/00 (2006.01) A61P 31/14 (2006.01) A61P 31/20 (2006.01)
Patent
CA 2704549
The present invention relates to the use of oligonucleotides having modified nucleobases to inhibit gene expression and/or replication of viruses in a subject. The modified nucleobases may be mercapto-modified bases or hydroxy-modified nucleobases. It is contemplated that the oligonucleotides further comprise a nuclease complex which enhances anti-viral activity of the oligonucleotides.
La présente invention concerne l'utilisation d'oligonucléotides ayant des nucléobases modifiées pour inhiber l'expression génique et/ou la réplication de virus chez un sujet. Les nucléobases modifiées peuvent être des bases modifiées par mercapto ou des nucléobases modifiées par hydroxy. Il est envisagé que les oligonucléotides comportent en outre un complexe de nucléase pour augmenter l'activité antivirale des oligonucléotides.
Karelson Mati
Merits Andres
Saarma Mart
Baltic Technology Development Ltd.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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