Use of opioid antagonists to attenuate endothelial cell...

Details Use of opioid antagonists to attenuate endothelial cell... Use of opioid antagonists to attenuate endothelial cell...

A - Human Necessities

61

K

A61K 31/451 (2006.01) A61K 31/485 (2006.01) A61K 39/395 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2600350

The invention provides methods of attenuating, e.g., inhibiting or reducing, cellular proliferation and migration, particularly endothelial cell proliferation and migration, including that associated with angiogenesis, using opioid antagonists, including, but not limited to, those that are peripherally restricted antagonists.

L'invention concerne des procédés d'atténuation, par exemple, par inhibition ou réduction, de la prolifération et de la migration cellulaires, en particulier la prolifération et la migration des cellules endothéliales, y compris celles associées à l'angiogenèse, au moyen d'antagonistes opioïdes comprenant, de manière non exclusive, les antagonistes périphériquement restreints.

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