Use of opri lipoprotein from pseudomonas as a th1 inducing...

Details Use of opri lipoprotein from pseudomonas as a th1 inducing... Use of opri lipoprotein from pseudomonas as a th1 inducing...

A - Human Necessities

61

K

A61K 39/39 (2006.01) A61K 39/00 (2006.01) A61K 39/008 (2006.01) A61K 48/00 (2006.01) A61P 31/06 (2006.01) A61P 31/08 (2006.01) A61P 31/10 (2006.01) A61P 33/02 (2006.01) A61P 37/00 (2006.01) C07K 14/21 (2006.01) C07K 14/44 (2006.01) C07K 16/10 (2006.01)

Patent

CA 2400495

The present invention relates to the use of the major OprI lipoprotein of Pseudomonas aeruginosa to elicit a Type-1 immune response towards a heterologous antigen. The invention relates specifically to the use of Oprl - antigen fusion proteins to elicit said Typ-1 response. More particurarly, the present invention is directed to pharmaceutical formulations comprising Oprl and/or Oprl fusion proteins, optionnaly together with a suitable excipient, to stimulate the Th1 dependent, cellular immune response.

La présente invention porte sur l'utilisation de la lipoprotéine principale Oprl de Pseudomonas aeruginosa en vue de provoquer une réponse immune du Type-1 contre un antigène hétérologue. L'invention porte précisément sur la lipoprotéine Oprl protéines hybrides d'antigène servant à provoquer la réponse immune du Type-1. Plus précisément encore, la présente invention porte sur des préparations pharmaceutiques renfermant la lipoprotéine Oprl et/ou des protéines hybrides Oprl, éventuellement avec un excipient approprié, en vue de stimuler la réponse immune cellulaire dépendante de Th1.

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