Use of panton-valentine leukocidin for treating and...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/12 (2006.01) A61K 39/085 (2006.01) A61K 39/395 (2006.01) A61P 31/04 (2006.01) C07K 14/31 (2006.01)

Patent

CA 2611023

The present invention relates to compositions and methods for treating Staphylococcus aureus (S. aureus) infections. In particular, the present invention provides vaccines comprising a Panton- Valentine Leukocidin (PVL) antigen, antibodies which bind a PVL antigen and compositions containing the same, methods of making such compositions and methods for treating S. aureus infections, including those that are community acquired methicillin-resistant infections. The present invention also provides PVL antibodies, including PVL antibodies specific for a single PVL subunit, and PVL antigens, including conjugated and mutated PVL antigens.

La présente invention a trait à des compositions et des procédés pour le traitement d'infections causées par Staphylococcus aureus (S. aureus). En particulier, la présente invention a trait à des vaccins comportant un antigène de leucocidine de Panton Valentine (PVL), à des anticorps de liaison à l'antigène PVL et à des compositions en contenant, à des procédés de fabrication de telles compositions et à des procédés pour le traitement d'infections, y compris les infections d'origine communautaire résistantes à la méthicilline. La présente invention a également trait à des anticorps PVL, y compris des anticorps PVL spécifiques d'une sous-unité PVL unique, et des antigènes PVL, y compris des antigènes PVL conjugués et mutés.

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