Use of particulate contrast agents in diagnostic imaging for...

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/14 (2006.01) A61B 5/055 (2006.01) A61B 8/00 (2006.01) A61K 9/127 (2006.01) A61K 9/50 (2006.01) A61K 49/00 (2006.01) A61K 49/04 (2006.01) A61K 51/00 (2006.01)

Patent

CA 2327816

The present invention relates to a method of imaging of an animate human or non-human animal body, which method comprises: administering parenterally to said body a particulate material comprising a matrix or membrane material and at least one contrast generating species, which matrix or membrane material is responsive to a pre-selected physiological parameter whereby to alter the contrast efficacy of said species in response to a change in the value of said parameters; generating image data of at least part of said body in which said species is present; and generating therefrom a signal indicative of the value or variation of said parameter in said part of said body. The invention also relates to contrast media for imaging a physiological parameter.

La présente invention concerne un procédé permettant d'imager un corps humain ou animal vivant, ce procédé consistant : à administrer de manière parentérale à ce corps une substance particulaire renfermant une matière particulaire matricielle ou membranaire, ainsi qu'au moins une espèce de contraste, la matière matricielle ou membranaire répondant à un paramètre physiologique prédéfini afin de modifier l'efficacité de contraste de ladite espèce, suite à une modification de la valeur du paramètre susmentionné ; à produire des données images d'au moins une partie du corps dans lequel l'espèce est présente ; et enfin à produire, à partir de ces données, un signal indiquant la valeur ou la modification de la valeur dudit paramètre dans cette partie du corps. L'invention concerne également des substances de contraste permettant d'imager un paramètre physiologique.

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