Use of particulate vectors in immunomodulation

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/20 (2006.01) A61K 9/51 (2006.01) A61K 39/00 (2006.01) A61K 39/145 (2006.01) A61K 39/39 (2006.01) A61K 38/12 (2006.01)

Patent

CA 2406949

The invention concerns a method for improving immunomodulatory properties of a substance, other than an antigen, capable of modulating immune response. The invention is characterised in that it comprises the mixture of said substance with hydrophilic particles bearing or not bearing ionic ligands and optionally coated with a layer of amphiphilic compounds. The invention also concerns the resulting pharmaceutical compositions and their uses for treating and/or preventing cancers, viral diseases and infectious diseases.

La présente invention a pour objet un procédé pour améliorer les propriétés immunomodulatrices d'une substance, autre qu'un antigène, capable de moduler la réponse immunologique, caractérisé en ce qu'il comprend le mélange de ladite substance avec des particules hydrophiles portant ou non des ligands ioniques et éventuellement recouvertes d'une couche de composés amphiphiles. L'invention concerne aussi les compositions pharmaceutiques ainsi obtenues et leurs utilisations pour le traitement et/ou la prévention des cancers, des maladies virales et des maladies infectieuses.

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