Use of pax4 in pancreatic cell proliferation

Details Use of pax4 in pancreatic cell proliferation Use of pax4 in pancreatic cell proliferation

C - Chemistry, Metallurgy

12

N

C12N 15/861 (2006.01) C12N 5/071 (2010.01) A61K 35/39 (2006.01) A61K 48/00 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2576573

The present invention relates to an in vitro method for the generation and isolation of pancreatic .beta.-cells, comprising the steps of (a) contacting an adult cell derived from mammalian pancreatic islets or an explant culture of adult pancreatic islets with functional, wild-type Pax4; and (b) detecting and isolating, from said adult cell or explant culture, .beta.-cells that proliferate in response to the contact with Pax4. Furthermore, the use of functional, wild-type Pax4 for the preparation of a pharmaceutical composition for transplantation and/or tissue replacement is described.

La présente invention concerne un procédé in vitro servant à générer et à isoler des cellules .beta. pancréatiques, comprenant les étapes consistant à (a) mettre en contact une cellule adulte dérivée d'îlots pancréatiques d'un mammifère ou une culture d'explant d'îlots pancréatiques adultes avec le Pax4 de type sauvage fonctionnel ; et (b) détecter et isoler, à partir de ladite cellule adulte ou culture d'explant, des cellules .beta. qui prolifèrent en réponse au contact avec le Pax4. En outre, il est décrit l'utilisation du Pax4 de type sauvage fonctionnel pour la préparation d'une composition pharmaceutique servant à une transplantation et/ou au remplacement d'un tissu.

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