Use of pde7 inhibitors for the treatment of movement disorders

Details Use of pde7 inhibitors for the treatment of movement disorders Use of pde7 inhibitors for the treatment of movement disorders

A - Human Necessities

61

K

A61K 31/395 (2006.01) A61K 31/33 (2006.01) A61K 31/381 (2006.01) A61K 31/4162 (2006.01) A61K 31/4164 (2006.01) A61K 31/42 (2006.01) A61K 31/435 (2006.01) A61K 31/4985 (2006.01) A61K 31/519 (2006.01) A61K 31/527 (2006.01) A61P 25/14 (2006.01) A61P 25/16 (2006.01)

Patent

CA 2760786

A method of treating a movement abnormality associated with the pathology of a neurological movement disorder, such as Parkinson's disease or Restless Leg(s) Syndrome by administering a therapeutically effective amount of a PDE7 inhibitory agent. An aspect of the invention provides for the administration of a PDE7 inhibitory agent in conjunction with a dopamine agonist or precursor, such as levodopa. In another aspect of the invention, the PDE7 inhibitory agent may be selective for PDE7 relative to other molecular targets (i) known to be involved with the pathology of Parkinson's disease or (ii) at which other drug(s) that are therapeutically effective to treat Parkinson's disease act.

L'invention porte sur un procédé de traitement d'une anomalie du mouvement associée à la pathologie d'un trouble du mouvement neurologique tel que la maladie de Parkinson ou le syndrome des gens sans repos par l'administration d'une quantité thérapeutiquement efficace d'un agent inhibiteur de PDE7. Un aspect de l'invention porte sur l'administration d'un agent inhibiteur de PDE7 conjointement avec un agoniste ou précurseur de dopamine tel que le levodopa. Sous un autre aspect de l'invention, l'agent inhibiteur de PDE7 peut être sélectif pour PDE7 par rapport à d'autres cibles moléculaires (i) connues pour être mises en jeu dans la pathologie de la maladie de Parkinson ou (ii) sur lesquelles agissent d'autre(s) médicament(s) qui sont thérapeutiquement efficaces pour traiter la maladie de Parkinson.

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