Use of peg-derivatized lipids as surface stabilizers for...

Details Use of peg-derivatized lipids as surface stabilizers for... Use of peg-derivatized lipids as surface stabilizers for...

A - Human Necessities

61

K

A61K 9/51 (2006.01) A61K 9/14 (2006.01) A61K 47/34 (2006.01)

Patent

CA 2362508

Nanoparticulate compositions comprising an insoluble organic drug and at least one polyethylene glycol-derivatized lipid adsorbed on the surface of the drug are described. The polyethylene glycol-derivatized lipid can be a PEG- phospholipid, PEG-cholesterol, PEG-cholesterol derivative, PEG-vitamin A, PEG- vitamin E, or a mixture thereof. The compositions have an effective average particle size of less than about 1 micron. The invention also describes methods of making and using such compositions.

L'invention concerne des compositions de nanoparticules comportant un médicament organique insoluble et au moins un lipide dérivé du polyéthylène glycol adsorbé à la surface dudit médicament. Ledit lipide dérivé du polyéthylène glycol peut être un phospholipide-PEG, un cholestérol-PEG, un dérivé de cholestérol-PEG, de la vitamine A-PEG, de la vitamine E-PEG ou un mélange de ces composés. Ces compositions possèdent une dimension granulométrique moyenne efficace inférieure à 1 micron environ. L'invention se rapporte également à des procédés de fabrication et d'utilisation de ces compositions.

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