Use of penicillin-binding proteins or polynucleotides or...

Details Use of penicillin-binding proteins or polynucleotides or... Use of penicillin-binding proteins or polynucleotides or...

A - Human Necessities

61

K

A61K 39/095 (2006.01) A61K 31/713 (2006.01) A61P 31/04 (2006.01) C07K 14/22 (2006.01) C07K 16/12 (2006.01) C12N 15/31 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2609043

The present invention is drawn to a penicillin-binding protein expressed by Neisseria meningitidis, or a fragment, or a variant, or a variant fragment thereof, or nucleic acids encoding them, or antibodies or antibody fragments directed against them, as medicaments or in pharmaceutical compositions. The invention is also directed to the use of penicillin-binding proteins expressed by Neisseria meningitidis, or nucleic acids encoding them, or antibodies directed against them for the prophylactic and/or therapeutic immunotherapy of mammals, preferably human beings, against infection by Neisseria meningitidis and/or by a bacterial strain expressing a variant of a Neisseria meningitidis penicillin-binding protein.

L'invention concerne une protéine se liant à la pénicilline exprimée par Neisseria meningitidis, ou un fragment, ou un variant ou un fragment de variant de celle-ci, ou des acides nucléiques codant celle-ci, ou des anticorps ou des fragments d'anticorps dirigés contre celle-ci, ainsi que des médicaments ou des compositions pharmaceutiques associées. L'invention concerne également l'utilisation de protéines se liant à la pénicilline exprimés par Neisseria meningitidis, ou d'acides nucléiques codant ces protéines, ou d'anticorps dirigés contre ces protéines pour une immunothérapie prophylactique et/ou thérapeutique de mammifères, de préférence des êtres humains, dirigée contre une infection provoquée par Neisseria meningitidis et/ou par une souche bactérienne exprimant un variant d'une protéine se liant à la pénicilline Neisseria meningitidis.

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