Use of peptides derived from the growth factor amp-18 for...

Details Use of peptides derived from the growth factor amp-18 for... Use of peptides derived from the growth factor amp-18 for...

A - Human Necessities

61

K

A61K 38/18 (2006.01) A61P 1/02 (2006.01)

Patent

CA 2643736

Methods and compositions of AMP- 18 derived peptides enablingly demonstrate that AMP-18 derived peptide compositions surprisingly reduce mucositis in mammals. Methods and peptide compositions treat mucositis, delays the onset or duration of mucositis, including cancer therapy-induced mucositis are disclosed. AMP 77-97 peptide derived from human AMP-18 protein alleviates cancer therapy-induced mucositis.

La présente invention concerne des procédés et des compositions à base de peptides dérivés d'AMP-18, qui font la preuve de façon validante que les compositions à base de peptides dérivés d'AMP-18 atténuent de façon surprenante la mucosite chez les mammifères. L'invention concerne notamment des procédés et des compositions qui traitent la mucosite, qui retardent la survenue ou la durée de la mucosite, y-compris les mucosites induites par les thérapies anticancéreuses. Les peptides AMP 77-97 dérivés de la protéine AMP-18 humaine atténuent les mucosites induites par les thérapies anticancéreuses.

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