Use of ph-responsive polymers

Details Use of ph-responsive polymers Use of ph-responsive polymers

B - Operations, Transporting

01

D

B01D 15/08 (2006.01) G01N 30/48 (2000.01)

Patent

CA 2517788

The present invention relates to a method of isolating target compounds from a liquid, which comprises at a first pH, contacting the liquid with a separation medium that exhibits surface-localised pH-responsive polymers in to adsorb the target compound via hydrophobic interactions; and adding an eluent, which is of a second pH and provides a conformational change of said pH-responsive polymers to release said compounds. The elution is advantageously performed by a pH gradient and/or by a salt gradient.

L'invention concerne un procédé permettant d'isoler des composés cibles d'un liquide, qui comporte les étapes consistant à : mettre le liquide en contact, à un premier pH, avec un milieu de séparation qui présente des polymères sensibles au pH localisés en surface afin d'adsorber le composé cible par des interactions hydrophobes ; et ajouter un éluant, qui présente un deuxième pH et produit un changement de conformation sur lesdits polymères, pour libérer les composés. L'élution est avantageusement mise en oeuvre au moyen d'un gradient de pH et/ou d'un gradient de sel.

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