Use of phenol soluble modulins for the development of vaccines

Details Use of phenol soluble modulins for the development of vaccines Use of phenol soluble modulins for the development of vaccines

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) C12N 5/078 (2010.01) A61K 39/00 (2006.01) A61K 39/385 (2006.01) A61K 39/39 (2006.01) C07K 14/31 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2745603

The invention relates to methods for increasing immunogenicity of an antigenic peptide by means of its covalent coupling to a modulin derived peptide (PSM, phenol soluble modulin). In particular, the binding of PSM.alpha., PSM.gamma. and PSM.delta. peptides to an antigen (from a pathogen or a tumor associated protein) increases the capacity of the antigen to activate an immune response in vivo. Thus, the PSM.alpha., PSM.gamma. and PSM.delta. peptides bound to these antigens may be used in the development of vaccines for preventing or treating infectious diseases or cancer

L'invention concerne des procédés pour augmenter l'immunogénicité d'un peptide antigène par l'intermédiaire de sa liaison par covalence à un peptide dérivé de la moduline (PSM, moduline phénol-soluble). En particulier, la liaison des peptides PSMa, PSlM? et PSMd à un antigène (issu d'un pathogène ou d'une protéine associée à une tumeur) augmente la capacité de l'antigène à activer une réaction immunitaire in vivo. Les peptides PSMa, PSMY et PSMd liés à ces antigènes peuvent ainsi être employés pour le développement de vaccins utilisés dans la prévention ou le traitement de maladies infectieuses ou du cancer.

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