Use of phenoxy pyridine derivatives for the treatment of...

A - Human Necessities – 61 – K

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A61K 31/44 (2006.01) A61K 31/4418 (2006.01)

Patent

CA 2222226

The invention is concerned with the use of compounds of general formula (I), wherein R1 signifies hydrogen, lower-alkyl, halogen, lower-alkoxy or nitro; R2 signifies hydrogen, lower alkyl or trifluoromethyl; and R3 signifies hydrogen, lower alkyl, trifluoromethyl, benzyl, hydroxy-lower-alkyl, lower alkoxy, lower- alkyl-carbonyl-amino, carbonyl-lower-alkyl, benzyl, di-lower-alkyl-amino- carbonyl, carbonyl-amino or amino-carbonyl-amino; or R2 and R3 together optionally signify a fused benzene ring and R4 signifies hydrogen or halogen, as well as pharmaceutically acceptable salts of compounds of general formula (I), for the treatment or prevention of illnesses which are caused by disorders of the dopamine system and, respectively, for the production of corresponding medicaments.

La présente invention se rapporte à l'utilisation de composés de formule générale (I), dans laquelle R?1¿ représente hydrogène, alkyle inférieur, halogène, alcoxy inférieur ou nitro; R?2¿ représente hydrogène, alkyle inférieur ou trifluorométhyle; et R?3¿ représente hydrogène, alkyle inférieur, trifluorométhyle, benzyle, hydroxy-alkyle inférieur, alcoxy inférieur, alkyle inférieur-carbonyl-amino, carbonyl-alkyle inférieur, benzyle, di-alkyle inférieur-amino-carbonyle, carbonyl-amino ou amino-carbonyl-amino; ou R?2¿ et R?3¿ représentent ensemble optionnellement un cycle de benzène fusionné, et R?4¿ représente hydrogène ou halogène, ainsi que des sels pharmaceutiquement acceptables des composés de formule générale (I), dans le traitement ou la prévention de pathologies causées par des troubles du système dopaminergique et, respectivement, pour la fabrication des médicaments correspondants.

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