Use of phosphatases to treat tumors overexpressing n-cor

A - Human Necessities – 61 – K

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A61K 31/34 (2006.01) A61K 31/165 (2006.01) A61K 31/19 (2006.01) A61K 31/203 (2006.01) A61K 31/35 (2006.01) A61K 38/50 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2641308

This invention provides a method of treating a patient suffering from a tumor overexpressing N-CoR comprising administering to the patient a phosphatase ligand, alone or in combination with "a retinoid receptor ligand, a histone deacetylase ligand, or both, in amounts effective to treat the patient. This invention also provides a method of inhibiting tumor growth in a patient suffering from a tumor overexpressing N-CoR. This invention further provides a method of identifying a compound or a mixture of compounds capable of inducing differentiation of cells of a tumor overexpressing N- CoR. This invention still further provides a method of determining the likelihood of successfully treating a subject suffering from a tumor overexpressing N-CoR. This invention also provides a method of assessing the- likelihood that a patient is suffering from a tumor overexpressing N-CoR. This invention yet also provides a method of assessing the likelihood that a patient previously suffering from and treated for a tumor overexpressing N-CoR has suffered a recurrence of a tumor overexpressing N-CoR. Finally, this invention provides analogous methods for use on glioblastoma multiforme.

La présente invention concerne un procédé de traitement de patients qui souffrent d'une tumeur qui surexprime N-CoR ; il consiste à administrer au patient un ligand phosphatase, seul ou combiné à un ligand de récepteur rétinoïde, un ligand d'histone déacétylase ou les deux, en quantités effectives pour traiter le patient. Cette invention propose aussi un procédé d'inhibition de croissance de tumeur chez un patient souffrant d'une tumeur surexprimant N-CoR. Cette invention propose aussi un procédé d'identification de composé ou un mélange de composés capable d'induire la différentiation de cellules d'une tumeur surexprimant N- CoR. Cette invention propose aussi un procédé de détermination de la vraisemblabilité de succès du traitement d'un patient souffrant d'une tumeur surexprimant N-CoR. Cette invention propose aussi un procédé d'évaluation de la vraisemblabilité qu'un patient souffre de cette tumeur. Cette invention propose aussi un procédé d'évaluation de la vraisemblabilité qu'un patient qui souffrait préalablement de cette tumeur et qui a reçu un traitement, souffre d'une récurrence de cette même tumeur. Finalement, cette invention propose des procédés analogiques d'utilisation de glioblastome multiforme.

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