Use of phosphodiesterase antagonists to treat insulin...

Details Use of phosphodiesterase antagonists to treat insulin... Use of phosphodiesterase antagonists to treat insulin...

A - Human Necessities

61

K

A61K 31/00 (2006.01) A61K 31/40 (2006.01) A61K 31/4166 (2006.01) A61K 31/4375 (2006.01) A61K 31/444 (2006.01) A61K 31/445 (2006.01) A61K 31/4709 (2006.01) A61K 31/505 (2006.01) A61K 31/519 (2006.01) A61K 31/52 (2006.01) A61K 31/522 (2006.01) A61K 31/53 (2006.01) A61K 45/06 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2514081

There is provided the use of a phosphodiesterase antagonist to reduce insulin resistance, and to amplify the effect of nitric oxide on skeletal muscle insulin-mediated glucose uptake in a mammal. In some instances, the antagonist is targeted to the liver. In some instances, the insulin resistance is hepatic insulin sensitizing substance ("HISS") dependant insulin resistance.

L'invention concerne l'utilisation d'un antagoniste de la phosphodiestérase en vue de réduire la résistance à l'insuline, et à amplifier l'effet de l'oxyde nitrique sur l'absorption du glucose par les muscles du squelette chez un mammifère. Dans certains cas, l'antagoniste est ciblé vers le foi. Dans certains cas, la résistance à l'insuline est une résistance à l'insuline dépendant de la substance sensibilisant à l'insuline hépatique ("SSIH").

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