C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
167/250, 260/460
C07F 9/09 (2006.01) A61K 31/685 (2006.01) C07F 9/10 (2006.01) C07F 9/165 (2006.01)
Patent
CA 2023944
The present invention is concerned with the use of compounds of the general formula:- Image wherein X is a valency bond, an oxygen or sulphur atom, a sulphinyl, sulphanyl, aminocarbonyl, carbonylamino or ureido group or a C3-C8-cycloalkylene or phenylene radical, Y is an oxygen or sulphur atom, R1 is a hydrogen atom or a straight-chained or branched, saturated or unsaturated alkyl radical containing up to 18 carbon atoms which is optionally substituted one or more times by phenyl, halogen, C1-C4-alkoxy, C1-C4- alkylmercapto, C1-C4-alkoxycarbonyl, C1-C4-alkane- sulphinyl or C1-C4-alkanesulphonyl, R2 is a straight- chained or branched, saturated or unsaturated alkylene chain containing up to 18 carbon atoms which is optionally substituted one or more times by halogen, phenyl, C1-C4-alkoxy, C1-C4-alkoxycarbonyl, C1-C4- alkylmercapto, C1-C4-alkanesulphinyl or C1-C4-alkane- sulphonyl, R3 is a straight-chained or branched, saturated or unsaturated alkylene chain containing 2 to 8 carbon atoms in which one methylene moiety can, be replaced by a C5-C7-cycloalkane ring and which is optionally substituted one or more times by hydroxyl, halogen, nitrile, C5-C7-cycloalkyl, phenyl, C1-C20- alkoxycarbonyl, C1-C20-alkylcarbamoyl, C1-C20-alkyl- mercapto, C1-C20-alkanesulphinyl, C1-C20-alkanesulphonyl or C1-C20-acylamino or by C1-C20-alkoxy which, in turn, can be substituted by phenyl, C1-C20 alkylmercapto, C1-C20-alkanesulphinyl, C1-C20-alkanesulphonyl, C1-C20 acylamino, C1-C20-allcoxycaxbonyl, nitrile, hydroxyl, C1-C20-alkoxy or C1-C20-alkylcarbamoyl, R4 is a straight-chained or branched alkylene chain containing 2 to 4 carbon atoms, R5 is a hydrogen atom or a C1-C6- alkyl radical and the three substituents R5 on the nitrogen atom can be the same or different and n is 0, 1 or 2, and of the pharmacologically acceptable salts thereof, as well as of the optical isomers thereof for their antiviral and antiretroviral action; the invention also provides new phospholipid derivatives within formula (I).
Bosies Elmar
Herrmann Dieter
Koch Edith
Zilch Harald
Bosies Elmar
Heidelberg Pharma Holding Gmbh
Herrmann Dieter
Koch Edith
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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