A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/70 (2006.01) A61K 31/675 (2006.01) C07F 9/6512 (2006.01) C07F 9/6561 (2006.01)
Patent
CA 2185699
Methods for treatment of conditions of abnormally increased intraocular pressure, particularly those caused by glaucoma, by administration of phosphonylmethoxyalkyl nucleoside analogs are provided. Compositions formulated and packaged for intraocular administration for use in the methods are also provided. Administration of the compound may be by intravitreal injection, aqueous humor injection, injection into the external layers of the eye, such as subconjunctival injection or subtenon injection, or may be, when penetrating derivatives are used, by topical application to the eye. The degree of reduction in pressure is dosage-dependent, and significant reduction in pressure is obtained. A single injection can produce prolonged, and perhaps permanent, lowering of the intraocular pressure.
Méthodes de traitement de la pression intra-oculaire élevée telle que le glaucome par administration d'analogues de nucléosides de phosphonylméthoxyalkyle, et compositions préparées et conditionnées pour une administration intra-oculaire, utilisées selon lesdites méthodes. L'administration du composé peut se faire par injection intravitréenne, dans l'humeur aqueuse, dans les couches externes de l'oeil tel que par injection subconjonctivale ou subtenonale ou, en cas d'utilisation de dérivés pénétrants, par des applications locales. Le taux de réduction de la pression, significatif, est fonction du dosage, une seule injection pouvant abaisser la pression intra-oculaire de façon durable et même définitive.
Freeman William R.
Smart & Biggar
LandOfFree
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