Use of phthalazine derivatives

Details Use of phthalazine derivatives Use of phthalazine derivatives

A - Human Necessities

61

K

A61K 31/00 (2006.01) A61K 31/502 (2006.01)

Patent

CA 2372704

The invention relates to the use of phthalazine derivatives as inhibitors of the enzyme poly(ADP-ribose)polymerase or PARP (EC 2.4.2.30), and to their use as inhibitors of PARP-homologous enzymes. These phthalazine derivatives also exhibit, in particular, a selective inhibition of the PARP-homologous enzymes.

L'invention concerne l'utilisation de dérivés de phtalazine comme inhibiteurs de l'enzyme poly(ADP-ribose)polymérase ou PARP (EC 2.4.2.30) et leur utilisation comme inhibiteurs d'enzymes PARP-homologues. Ces dérivés de phtalazine exercent notamment une inhibition sélective des enzymes PAR-homologues.

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