Use of piperazine derivatives as ccr1 antagonists

A - Human Necessities – 61 – K

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A61K 31/495 (2006.01) A61P 37/02 (2006.01)

Patent

CA 2498261

The present invention relates to compounds of the formula (I) and the pharmaceutically acceptable forms thereof; wherein X, Y, a, b, c, d, R1, R2, R3, R4 and R5 are as defined herein. Moreover, the present invention is also directed at pharmaceutical compositions comprising a compound of the formula (I) and a pharmaceutically acceptable carrier. Furthermore, the present invention is directed at methods of using the herein described compounds and compositions for treating or preventing a disorder or condition that can be treated or prevented by antagonizing the CCR1 receptor in a mammal.

L'invention porte sur des composés de la formule (I) et sur des formes pharmaceutiquement acceptables de ce dernier, X, Y, a, b, c, d, R?1¿, R?2¿, R?3¿, R?4¿ et R?5¿ étant tels que décrits ci-contre. De plus, l'invention concerne aussi des compositions pharmaceutiques contenant un composé de la formule (I) et un excipient pharmaceutiquement acceptable. En outre, l'invention se rapporte à des procédés d'utilisation des composés susmentionnés et des compositions pour le traitement ou la prévention d'un trouble ou d'une condition que l'on peut traiter ou prévenir par antagonisation du récepteur CCR1 chez un mammifère.

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