A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/40 (2006.01) A61K 31/00 (2006.01) A61K 31/407 (2006.01)
Patent
CA 2323176
Methods for inhibiting activation and/or proliferation of T cells and B cells and for treating autoimmune diseases and/or disease manifestations are disclosed, particularly using the isozyme selective PKC inhibitor, (S)-3,4- [N,N'-1,1'-((2''-ethoxy)-3'''(O)-4'''-(N,N-dimethylamino)-butane)-bis-(3,3'- indolyl)]-1(H)-pyrrole-2,5-dione and its pharmaceutically acceptable salts.
Cette invention se rapporte à des procédés servant à inhiber l'activation et/ou la prolifération de lymphocytes T et de lymphocytes B et servant à traiter les maladies auto-immunes et/ou des manifestations pathologiques de ces maladies, notamment en utilisant l'inhibiteur de protéine-kinase C (PKC) à sélectivité pour les isozymes, (S)-3,4-[N,N'-1,1'-((2''-éthoxy)-3'''(O)-4'''-(N,N-diméthylamino)-butane)-bis-(3,3'-indolyl)]-1(H)-pyrrole-2,5-dione et ses sels acceptables sur le plan pharmaceutique.
Ways Douglas Kirk
Wierda Daniel
Eli Lilly And Company
Gowling Lafleur Henderson Llp
LandOfFree
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