Use of pla2 inhibitors as treatment for alzheimer's disease

Details Use of pla2 inhibitors as treatment for alzheimer's disease Use of pla2 inhibitors as treatment for alzheimer's disease

A - Human Necessities

61

K

A61K 31/41 (2006.01) A61K 31/00 (2006.01) A61K 31/165 (2006.01) A61K 31/18 (2006.01) A61K 31/19 (2006.01) A61K 31/35 (2006.01)

Patent

CA 2179649

This invention provides methods for the treatment or prevention of Alzheimer's disease in a mammal which comprises administering to a mammal in need thereof an effective amount of an inhibitor of phospholipase A2. This invention also provides a series of compounds which are useful as inhibitors of phospholipases A2, especially cytosolic phospholipase A2.

L'invention se rapporte à des procédés de traitement ou de prévention de la maladie d'Alzheimer chez un mammifère, ce procédé consistant à administrer à un mammifère nécessitant un tel traitement une dose efficace d'un inhibiteur de phospholipase A¿2? (PLA¿2?). L'invention se rapporte également à une série de composés aptes à être utilisés comme inhibiteurs de phospholipases A¿2?, en particulier de la phospholipase A¿2? cytosolique.

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