Use of poly-alpha2,8-sialic acid mimetic peptides to...

Details Use of poly-alpha2,8-sialic acid mimetic peptides to... Use of poly-alpha2,8-sialic acid mimetic peptides to...

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/12 (2006.01) C07K 1/04 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 7/64 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2501994

The invention relates to the use of a peptide consisting of 5 to 30 amino acid residues, preferably 9 to 15, most preferably about 12 amino acid residues, said peptide comprising a B epitope of a poly-.alpha.2,8 sialic acid attached to NCAM, which is recognized by an anti-poly-.alpha.2,8 sialic acid (PSA) antibody, for the preparation of a medicament for modulating NCAM functions, to be administered for the prevention and/or the treatment of neurodegenerative diseases, brain and spine lesions, age-related learning and memory problems, and cancer.

Utilisation d'un peptide constitué de 5 à 30 restes d'acides aminés, de préférence de 9 à 15, et idéalement d'environ 12 restes d'acides aminés, ledit peptide comportant un épitope B d'un acide poly-.alpha.2,8sialique attaché à la molécule d'adhérence cellulaire neuronale (NCAM), qui est reconnu par un anticorps anti-acide poly-.alpha.2,8sialique (PSA), pour la préparation d'un médicament destiné à moduler les fonctions de NCAM et à être administré pour prévenir et / ou traiter des maladies neurodégénératives, des lésions cérébrales et médullaires, les problèmes d'apprentissage et de mémoire liés à l'âge et le cancer.

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