C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/4375 (2006.01) A61P 35/00 (2006.01) C07D 221/00 (2006.01)
Patent
CA 2417473
The invention concerns the use of aromatic compounds capable of binding with G-quadruplex structures to produce medicines with anti-telomerase effect. Said compounds correspond to formula (I) wherein: R¿1?, R¿2? and R¿3?, identical or different, represent a hydrogen atom, or a -CH¿2?-NH-(CH¿2?)¿n?-X group, wherein n is an integer from 2 to 4, and X is selected among -NH¿2?-, -N(CH¿3?)¿2? radicals, a heterocyclic radical such as piperidyl, imidazolyl, morpholinyl radical, or an indole-type condensed heterocyclic radical, -Z represents CH or N, each compound comprising two nitrogen atoms in the Z positions. The invention is useful for producing anticancer medicines.
L'invention vise l'utilisation de composés aromatiques capables de se lier à des structures G-quadruplex pour fabriquer des médicaments à effet anti- télomérase. Ces composés répondent à la formule (I) dans laquelle-- R1, R2 et R3, identiques ou différents l'un de l'autre, représentent un atome d'hydrogène, ou un groupe - CH2 - NH - (CH2)n - X, dans lequel n est un entier de 2 à 4, et X est choisi parmi les radicaux - NH2, - N (CH3)2, un radical hérocyclique comme le radical pipéridyle, imidazolyle, morpholinyle, ou un radical hétérocylique condensé de type indole,- Z représente CH ou N, chaque composé comportant deux azotes sur les positions "Z". Application à la fabrication de médicaments anti-cancéreux.
Helene Claude
Lacroix Laurent
Lehn Jean-Marie
Mergny Jean-Louis
Teulade-Fichou Marie-Paule
Centre National de La Recherche Scientifique (c.n.r.s.)
Institut National de La Sante Et de La Recherche Medicale (i.n.s
Museum National D'histoire Naturelle
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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