A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/575 (2006.01)
Patent
CA 2302243
In accordance with the present invention, there are provided methods for the treatment of cystic renal diseases, vascular infarction, catabolic and growth consequences of uremia and other related indications in mammals, employing members of a defined class of polycyclic compounds as the active agent. In accordance with another embodiment of the present invention, it has been discovered that these compounds are effective agents for the treatment of renal dysplasias and/or renal hypoplasias in mammals. In accordance with yet another embodiment of the present invention, it has been discovered that these compounds are effective agents for enhancing glomerular development in mammals. In accordance with still another embodiment of the present invention, it has been discovered that these compounds are effective agents for enhancing kidney development in mammals suffering from chronic organ injury. In accordance with a further embodiment of the present invention, it has been discovered that these compounds are effective agents for protecting kidneys from the ongoing toxicity of treatment with steroid hormones. In accordance with a still further embodiment of the present invention, it has been discovered that these compounds are effective agents for maintaining substantially normal growth in neonates, pre-pubescent and pubertal mammals exposed to high dose steroid hormone therapy and improves the poor growth associated with the catabolic effects of chronic disease or uremia in these mammals. In accordance with yet a further embodiment of the present invention, it has been discovered that these compounds prevent or treat organ vascular infarction in mammals.
La présente invention concerne des procédés permettant de traiter les maladies kystiques rénales, l'infarctus vasculaire, les conséquences de l'urémie sur le catabolisme et la croissance et autres indications associées chez les mammifères, lesquels procédés font appel, comme principe actif, à des éléments d'une classe définie de composés polycycliques. Selon un autre mode de réalisation de la présente invention, ces composés constituent des substances efficaces pour le traitement des dysplasies et/ou hypoplasies rénales chez les mammifères. Et dans différents autres modes de réalisation de la présente invention, ces composés constituent des substances efficaces permettant, respectivement, de favoriser le développement glomérulaire chez les mammifères; d'améliorer le développement rénal chez des mammifères souffrant d'une lésion organique chronique; de protéger les reins de la toxicité persistante des traitements aux hormones stéroïdes; ainsi que de maintenir une croissance sensiblement normale chez des mammifères néonates, prépubères et pubères exposés à une thérapie faisant appel à des doses élevées d'hormones stéroïdes et d'améliorer la faible croissance associée aux effets d'une maladie chronique ou de l'urémie sur le catabolisme de ces mammifères. Selon encore un autre mode de réalisation, ces composés permettent de prévenir ou de traiter l'infarctus vasculaire organique chez les mammifères.
Acott Philip D.
Crocker John F. S.
Dalhousie University
Smart & Biggar
LandOfFree
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