Use of poxviruses as enhancer of specific immunity

Details Use of poxviruses as enhancer of specific immunity Use of poxviruses as enhancer of specific immunity

A - Human Necessities

61

K

A61K 39/39 (2006.01) A61K 35/76 (2006.01) A61K 39/00 (2006.01) A61K 39/145 (2006.01) A61K 39/21 (2006.01)

Patent

CA 2335508

The invention relates to a method for enhancing the specific immune response against an immunogenic compound which comprises administering the immunogenic compound together with a poxvirus recombinant and a vaccinal antigen, which is not a poxvirus. The immunological material may be any biological material useful as a vaccine e.g., a polypeptide characteristic of a pathogenic microorganism or associated with a tumoral disorder, a DNA plasmid encoding a peptide or a polypeptide characteristic of a pathogenic microorganism or a tumor-associated antigen, or an hapten coupled to a carrier molecule. The poxvirus may be a live, attenuated or inactivated virus or a recombinant virus. Recombinant virus may encode a heterologous polypeptide such as chemokines, cytokines or co-immunostimulatory molecules or an homologous polypeptide, which is immunologically cross reactive with the immunogenic polypeptide or peptide.

L'invention concerne un procédé visant à renforcer la réponse immunitaire spécifique dirigée contre un composé immunogénique qui consiste à administrer le composé immunogénique conjointement avec un poxvirus recombinant et un antigène vaccinal qui n'est pas un poxvirus. La matière immunologique peut se présenter comme n'importe quelle matière biologique utilisable comme vaccin, p.ex. un polypeptide caractéristique d'un micro-organisme pathogène ou associé à un trouble tumoral, un plasmide d'ADN codant pour un peptide ou un polypeptide caractéristique d'un micro-organisme pathogène ou d'un antigène associé à une tumeur, ou un haptène couplé à une molécule porteuse. Le poxvirus peut être vivant, atténué ou inactivé, ou encore un virus recombinant. Les virus recombinants peuvent coder pour un polypeptide hétérologue tel que des chimiokines, des cytokines ou des molécules co-immunostimulatoires ou un polypeptide homologue qui manifeste des réactions immunologiques croisées avec le polypeptide ou le peptide immunogénique.

Affiliated with

Also associated with

Rating

Use of poxviruses as enhancer of specific immunity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Use of poxviruses as enhancer of specific immunity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of poxviruses as enhancer of specific immunity will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1361334