Use of ppar agonists to treat ruminants

Details Use of ppar agonists to treat ruminants Use of ppar agonists to treat ruminants

A - Human Necessities

61

K

A61K 31/192 (2006.01) A23K 1/16 (2006.01) A23K 1/18 (2006.01) A61K 31/451 (2006.01) A61P 1/00 (2006.01) A61P 1/16 (2006.01) A61P 3/00 (2006.01) A61P 15/00 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2568009

The use of a PPAR agonist in the manufacture of a medicament to increase ruminant serum glucose concentrations, and preferably, the use for the palliative, prophylactic or curative treatment of ruminant disease associated with reduced serum glucose concentration. The ruminant disease associated with reduced serum glucose concentration includes fatty liver syndrome, dystocia, immune dysfunction, impaired immune function, toxif ication, primary ketosis, secondary ketosis, downer cow syndrome, indigestion, inappetence, retained placenta, displaced abomasum, mastitis, (endo-) -metritis, infertility, low fertility, lameness, subacute rumen acidosis and inadequate nutrient intake associated with stress e.g. heat, poor housing, overcrowding, shipping, dominance or illness, and to increase milk quality and yield.

L'invention concerne l'utilisation d'un agoniste PPAR pour produire un médicament destiné à augmenter les concentrations de glucose sérique chez les ruminants, et plus particulièrement son utilisation pour le traitement palliatif, prophylactique ou curatif de maladies de ruminants associées à une concentration réduite de glucose sérique. Les maladies de ruminants associées à une concentration réduite de glucose sérique comprennent le syndrome de la toxémie de gestation de la vache, la dystocie, le dysfonctionnement immunitaire, l'altération de la fonction immunitaire, la contamination toxique, la cétose primaire, la cétose secondaire, le syndrome de la vache à terre, l'indigestion, l'anorexie, la rétention du placenta, le déplacement de la caillette, la mammite, l'(endo)métrite, l'infertilité, la faible fertilité, la boiterie, l'acidose subaiguë du rumen et l'absorption inadéquate d'aliment associée à un stress comme la chaleur, le logement insalubre, l'entassement, le transport, la dominance ou la maladie.

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