Use of ppar alpha agonists for the treatment of vascular and...

Details Use of ppar alpha agonists for the treatment of vascular and... Use of ppar alpha agonists for the treatment of vascular and...

A - Human Necessities

61

K

A61K 31/216 (2006.01) A61K 31/192 (2006.01) A61P 9/00 (2006.01) A61P 13/00 (2006.01)

Patent

CA 2481371

Activation of peroxisome proliferator activated receptor alpha (PPAR.alpha.) by administration of therapeutic amounts of a PPAR.alpha. agonist, WY-14643, inhibits the proliferation of vascular smooth muscle cells, hepatoma cells and human renal proximal tubule cells. WY-14643 may be applicable as a medicament for the treatment of proliferative vascular disease (atherosclerosis, hypertension), revascularization-induced injury (restenosis) and chronic renal failure.

L'invention concerne l'activation du récepteur alpha activé par les proliférateurs de peroxysome (PPAR?) par administration de quantités thérapeutiques d'un agoniste de PPAR?.alpha., WY-14643, inhibant la prolifération de cellules du muscle lisse vasculaire, de cellules hépatomiques et de cellules tubulaires proximales rénales humaines. WY-14643 peut être utilisé comme un médicament destiné au traitement de maladies prolifératives (athérosclérose, hypertension), d'une blessure induite par revascularisation (resténose) et de l'insuffisance rénale chronique.

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