A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)
Patent
CA 2281934
The present invention relates to the use of anti-CD44 antibodies from the constant portion (sDC44) and variable portion of CD44 (VCD44) in the treatment of certain tumours and other diseases which are associated with degeneracy and activation of Langerhans cells (LC) and dendritic cells (DC) in the body of a mammal including human beings, and in the treatment of undesirable immune reactions. The invention also relates to an ex vivo culture method for the production of dendritic cells.
L'invention concerne l'utilisation d'anticorps anti-CD44 provenant de la partie constante (sCD44) et de la partie variable (vCD44) du CD44 pour traiter certaines tumeurs et d'autres maladies associées à une dégénérescence et à une activation des cellules de Langerhans (LC) et des cellules dendritiques (DC) d'un organisme de mammifère, y compris l'homme, ainsi que pour traiter des réactions immunitaires indésirables. L'invention concerne également une technique de culture ex vivo permettant de produire des cellules dendritiques.
Herrlich Peter
Ponta Helmut
Simon Jan
Weiss Johannes
Boehringer Ingelheim International Gmbh
Fetherstonhaugh & Co.
Forschungszentrum Karlsruhe Gmbh
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