Use of prion conversion modulating agents

G - Physics – 01 – N

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Details

G01N 33/68 (2006.01) A61K 31/00 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) C07K 14/775 (2006.01) C12Q 1/68 (2006.01) G01N 33/92 (2006.01)

Patent

CA 2525517

The use of Apolipoprotein B, Apoliporpotein E, fragments and mimetics thereof is provided for diagnostic, detection, prognostic and therapeutic applications in prion diseases. More specifically, the invention provides the use of Apolipoprotein B or fragments thereof for modulating or identifying modulators of the prion protein replication which are implicated in thepathogenesis of transmissible spongiform encephalopathics and other prion diseases.

L'invention concerne l'utilisation de l'apolipoprotéine B, de l'apolipoprotéine E, de fragments et de mimétiques de celles-ci pour des applications diagnostiques, de détection, pronostiques et thérapeutiques dans des maladies à prions. Plus particulièrement, l'invention concerne l'utilisation de l'apolipoprotéine B ou de fragments de celle-ci pour la modulation ou l'identification de modulateurs de la réplication de la protéine prion qui sont impliqués dans la pathogenèse des encéphalopathies spongiformes transmissibles et d'autres maladies à prions.

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