C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2336595
It has now been found that the introduction of single stranded oligonucleotides of DNA or RNA, particularly RNA transcribed from portions of wild type prohibitin 3'UTR, into tumors leads to arrested cell proliferation. Significant reduction in the size of primary tumors has been observed following direct administration of prohibitin 3'UTR RNA. Induction of systemic immunity, as evidenced by the disappearance of metastases as well as the lack of tumor growth in rechallenged animals following prohibitin RNA therapy, has been observed. Thus, wild type RNAs transcribed from portions of a prohibitin 3'UTR, or single stranded DNAs comprised of portions of a prohibitin 3'UTR, or synthetically-made oligonucleotides of the same sequences, can be directly administered as therapeutic agents against tumors.
On a découvert que l'introduction d'oligonucléotides d'ADN et d'ARN à un seul brin, en particulier d'ARN transcrit à partir de segments de prohibitine 3'UTR de type sauvage, dans des tumeurs provoquait l'arrêt de la prolifération cellulaire. On a observé une réduction importante de la taille de tumeurs primaires suite à l'administration directe d'ARN de prohibitine 3'UTR. On a également observé une induction de l'immunité systémique, telle que matérialisée par la disparition de métastases ainsi que le manque de croissance des tumeurs chez des animaux chez lesquels on a repris le traitement suite à un traitement par ARN de prohibitine. Ainsi, on peut directement administrer, comme agents thérapeutiques contre des tumeurs, des ARN de type sauvage transcrits à partir de segments de prohibitine 3'UTR, ou des ADN à un seul brin formés de segments de prohibitine 3'UTR, ou des oligonucléotides des mêmes séquences obtenus par synthèse.
Macrae & Co.
Oklahoma Medical Research Foundation
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