Use of proinsulin for the preparation of a neuroprotective...

Details Use of proinsulin for the preparation of a neuroprotective... Use of proinsulin for the preparation of a neuroprotective...

A - Human Necessities

61

K

A61K 38/28 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2652983

The present invention relates to the use of a compound that induces the activity of proinsulin, preferably human proinuslin, for the preparation of a medicinal product or pharmaceutical composition for the prevention and treatment of neurodegenerative conditions, disorders or diseases involving programmed cell death, preferably neurodegenerative pathologies of the central and peripheral nervous systems, and, more preferably, of the heredodegenerative diseases known as retinosis pigmentosa. The activator compound may consist of a chemical molecule, a peptide, a protein or a nucleotide sequence.

La présente invention concerne l'utilisation d'un composé induisant l'activité de la proinsuline, de préférence de la proinsuline humaine, pour l'élaboration d'un médicament ou d'une composition pharmaceutique destiné à la prévention et au traitement de troubles ou de maladies neurodégénératives liées à une mort cellulaire programmée, de préférence des pathologies neurodégénératives du système nerveux central et périphérique, et mieux encore du groupe de maladies héréditaires dégénératives connues sous le nom de rétinites pigmentaires. Le composé activateur peut être constitué d'une molécule chimique, d'un peptide, d'une protéine ou d'une séquence de nucléotides.

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