Use of pteridine derivatives as no-synthase inhibitors

A - Human Necessities – 61 – K

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A61K 31/519 (2006.01) A61K 31/505 (2006.01) C12N 9/99 (2006.01)

Patent

CA 2189131

The present invention relates to the use of pteridine derivatives of the formula I (see formula I) in which X is O, NH or N-(C1-C5)-alkanoyl, R3 is the radical -OR4, -NR5R6 or -S(O)m R7, and R, R1, R2, R4, R5, R6, R7 and m have the meanings given in claim 1, which are nitric oxide synthase inhibitors, for the treatment of diseases which are caused by an increased nitric oxide level.

L'invention concerne des dérivés de ptéridine de la formule générale (I), dans laquelle X désigne O, NH ou N-(C1-C5)-alcanoyle, R<3> désigne le reste -OR<4>, -NR<5>R<6> ou -S(O)mR<7> et R, R<1>, R<2>, R<4>, R<5>, R<6>, R<7> et m ont les notations mentionnées dans la revendication 1. Ces dérivés de ptéridine sont des inhibiteurs de la NO-synthase. L'invention concerne leur utilisation dans le traitement de maladies dues à une élévation du taux de monoxyde d'azote.

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