C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/32 (2006.01) A61K 31/445 (2006.01) C07C 57/145 (2006.01)
Patent
CA 2581926
The present invention provides a crystalline donepezil maleate, which is used as an intermediate in the preparation of donepezil hydrochloride. Also provided are novel processes for producing same in substantially pure form and a process for producing pharmaceutically pure amorphous donepezil hydrochloride therefrom.
La présente invention concerne un maléate de donépézil cristallin qui est utilisé comme intermédiaire dans la préparation d'hydrochlorure de donépézil. Cette invention concerne également des nouveaux procédés de production de celui-ci dans une forme substantiellement pure et un procédé de production d'hydrochlorure de donépézyl amorphe pharmaceutiquement pur.
Alnabari Mohammed
Arad Oded
Bentolila Moshe
Brand Michael
Gribun Irina
Chemagis Ltd.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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