C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2643362
The invention relates to methods of using the compounds of the invention, including pyrazolo[1,5a]pyrimidin-7-yl amine compounds and salts thereof, as well as pharmaceutical compositions comprising the same, in the treatment of Eph receptor-related (e.g., neurological) injuries and disorders. The invention also relates to modulating the activity of an Eph receptor in a cell, stimulating neural regeneration, and reversing neuronal degeneration, by administering a compound of the invention to a cell or subject in an effective amount.
La présente invention concerne des procédés d'utilisation des composés de l'invention, incluant des composés pyrazolo[1,5a]pyrimidin-7-yl amine et leurs sels, ainsi que des compositions pharmaceutiques les comprenant, dans le traitement de lésions et de troubles liés au récepteur de Eph (par exemple, neurologiques). L'invention concerne également la modulation de l'activité d'un récepteur Eph dans une cellule, la stimulation de la régénération neurale et l'inversion de la dégénérescence neuronale, par l'administration d'un composé de l'invention à une cellule ou à un patient en une quantité efficace.
Sivasankaran Rajeev
Zimmermann Kaspar
Fetherstonhaugh & Co.
Novartis Ag
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