C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/28 (2006.01) A61K 31/44 (2006.01) A61K 31/443 (2006.01) A61K 31/4433 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61P 19/00 (2006.01) C07D 213/81 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01)
Patent
CA 2469625
The invention concerns pyridine-2,4-dicarboxylic acid diamides and pyrimidine- 4,6-dicarboxylic acid diamides of formula (I) for selective collagenase (MMP 13) inhibition. Said pyridine-2,4- dicarboxylic acid diamides and pyrimidine-4,6-dicarboxylic acid diamides can therefore be used for treating degenerative joint diseases.
L'invention concerne des diamides d'acide pyridine-2,4-dicarboxylique et des diamides d'acide pyrimidine-4,6-dicarboxylique de formule (I) pour l'inhibition sélective de la collagénase (MMP 13). Ces diamides d'acide pyridine-2,4-dicarboxylique et diamides d'acide pyrimidine-4,6-dicarboxylique peuvent par conséquent être utilisés pour le traitement d'affections articulaires dégénératives.
Habermann Joerg
Kirsch Reinhard
Kogler Herbert
Wehner Volkmar
Weithmann Klaus-Ulrich
Aventis Pharma Deutschland Gmbh
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sanofi-Aventis Deutschland Gmbh
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