Use of r-10-hydroxy-10, 11-dihydro-carbamazepine in...

Details Use of r-10-hydroxy-10, 11-dihydro-carbamazepine in... Use of r-10-hydroxy-10, 11-dihydro-carbamazepine in...

A - Human Necessities

61

K

A61K 31/55 (2006.01) A61P 25/02 (2006.01)

Patent

CA 2516265

The present invention relates to the use of a mixture of the enantiomers of a compound of Formula (I) or of pharmaceutically acceptable salts of said enantiomers consisting of at least 55% of the R-enantiomer, most preferably of at least 98 % of the R-enantiomer, and not more than 45 % of the S-enantiomer, most preferably not more than 2 % of the Senantiomer, for the manufacture of a pharmaceutical composition for the treatment of neuropathic pain; to a method for the treatment of neuropathic pain; and to a pharmaceutical composition comprising as active agent a mixture of the enantiomers of the compound of formula I or pharmaceutically acceptable salts of said enantiomers consisting of at least 55 % of the R-enantiomer and not more than 45 % of the S- enantiomer.

L'invention concerne l'utilisation d'un mélange d'énantiomères d'un composé de formule (I) ou de sels acceptables sur le plan pharmaceutique desdits énantiomères, qui comprend au moins 55 % d'un énantiomère R, de préférence au moins 98 % de l'énantiomère R, et pas plus de 45 % d'un énantiomère S, de préférence pas plus de 2 % de l'énantiomère S, pour la production d'une composition pharmaceutique destinée au traitement des douleurs neuropathiques; une méthode de traitement des douleurs neuropathiques; et une composition pharmaceutique utilisant en tant que principe actif ledit mélange d'énantiomères du composé de formule (I) ou de sels acceptables sur le plan pharmaceutique desdits énantiomères, qui comprend au moins 55 % de l'énantiomère R et pas plus de 45 % de l'énantiomère S.

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