Use of radiolabeled monoclonal igm in therapy for cancer and...

Details Use of radiolabeled monoclonal igm in therapy for cancer and... Use of radiolabeled monoclonal igm in therapy for cancer and...

A - Human Necessities

61

K

A61K 51/10 (2006.01) A61K 31/385 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2318231

It has been discovered that large antibody aggregates or molecules, such as IgM or conjugated IgG or IgG fusion proteins, can be used to treat tumors by intracompartmental or intratumoral administration of anti-tumor antibody coupled to a toxin. The method can also be used in the treatment of certain disorders characterized by deposition of immune complex, for example, rheumatoid arthritis. In the preferred embodiment, the antibody is IgM and the toxin is a radioisotope, most preferably 111In-labelled IgM or 90Y-labelled IgM. Examples demonstrate effectiveness in mice models.

On a trouvé que l'on pouvait utiliser de grands agrégats d'anticorps ou des molécules telles que l'immunoglobuline M, l'immunoglobuline G conjuguée ou les protéines de fusion de l'immunoglobuline G pour traiter des tumeurs par administration intra-compartimentale ou intratumorale d'un anticorps antitumoral couplé à une toxine. Le traitement convient également contre certains troubles caractérisés par le dépôt d'un complexe immun, et notamment la polyarthrite rhumatoïde. Selon la réalisation préférée, l'anticorps est l'immunoglobuline M, et la toxine est un radio-isotope, et de façon plus préférentielle une immunoglobuline M radiomarquée par le ?111¿In ou le ?90¿Y. Les exemples mettent en évidence l'efficacité sur des modèles murins.

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