Use of radiolabeled peptide derived from crosslinked fibron...

Details Use of radiolabeled peptide derived from crosslinked fibron... Use of radiolabeled peptide derived from crosslinked fibron...

A - Human Necessities

61

K

167/47

A61K 49/00 (2006.01) A61K 51/08 (2006.01) C07K 14/78 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1198671

ABSTRACT OF THE DISCLOSURE A method of locating thrombi in vivo comprising the steps of administering a radiolabeled peptide selected from the group consisting of Fragment E1 isolated from cross linked fibrin, Fragment E2 isolated from cross- linked fibrin, and peptides having an amino acid sequence intermediate between Fragments E1 and E2 derived from crosslinked fibrin by plasmin digestion to a human or animal wherein the peptide is selectively incorporated or bound by forming a pre-formed thrombi and externally detecting the radiation emitted by the radiolabeled peptide. A composition containing the peptide used for locating thrombi is also disclosed.

399535

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