A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 51/00 (2006.01) A61K 51/04 (2006.01) A61K 51/10 (2006.01)
Patent
CA 2449941
Non-lethal methods of conditioning a recipient prior to bone marrow transplantation to achieve highly enhanced, stable, long-term hematopoietic chimerism in presence of transient immunosuppression are described. In particular, the administration of non-lethal doses of bone-seeking radiopharmaceuticals such as 153Samarium Lexidronam, a radioactive compound linked to a tetraphosphonate group, to target bone marrow cells, are disclosed herein.
L'invention concerne des procédés non mortels permettant de traiter le récepteur préalablement à une transplantation de moelle osseuse afin d'augmenter considérablement la stabilité et la durée à long terme du chimérisme hématopoïétique en présence d'une immunosuppression transitoire. En particulier, elle concerne l'administration de doses non mortelles de substances radiopharmaceutiques ostéotropes, telles que Samarium Lexidronam, composé radioactif lié à un groupe tétraphosphonate, afin de cibler les cellules de la moelle osseuse.
Inverardi Luca
Paganelli Giovanni
Ricordi Camillo
Serafini Aldo
Smart & Biggar
University Of Miami
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