G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/50 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2326141
The subject of the present invention is the use of the ROR receptors and/or of their response element or alternatively of a functional equivalent thereof for the screening of substances having antiatherosclerotic properties. The invention also relates to the methods of screening substances having antiatherosclerotic properties using the ROR receptors and/or their response elements. The invention also relates to the use of the methods of screening according to the present invention in order to characterize, justify and claim the mechanism of action of substances having antiatherosclerotic properties using the ROR receptors and/or their response elements as well as their effects on apo C-III.
Le sujet de la présente invention a trait à l'utilisation des récepteurs ROR et/ou de leurs éléments de réponse ou alternativement d'un équivalent fonctionnel de ceux-ci dans le criblage de substances ayant des propriétés antiathéroscléreuses. L'invention concerne également des méthodes de criblage de substances présentant des propriétés antiathéroscléreuses utilisant les récepteurs ROR et/ou leurs éléments de réponse. L'invention concerne en outre l'utilisation des méthodes de criblage selon la présente invention afin de caractériser, de justifier et de revendiquer le mécanisme d'action de substances ayant des propriétés antiathéroscléreuses utilisant les récepteurs ROR et/ou leurs éléments de réponse ainsi que leurs effets sur apo C-III.
Bonhomme Yves
Raspe Eric
Fetherstonhaugh & Co.
Merck Patent Gesellschaft Mit Beschraenkter Haftung
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