G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/566 (2006.01) C12Q 1/68 (2006.01) G01N 33/92 (2006.01)
Patent
CA 2336009
The present invention relates to the use of receptors of the Rev-erb family to screen substances which are useful in the treatment of lipid metabolism dysfunctions associated with apolipoprotein C-III. The invention relates more particularly to screening methods for selecting substances which are useful for the treatment of these dysfunctions. Lastly, the invention relates to the use of the substances thus identified for the preparation of therapeutic compositions which are useful for the treatment of lipid metabolism dysfunctions associated with apolipoprotein C-III. The subject of the present invention is also the use of screening tests for the characterization, justification and claim of the mechanism of action of substances possessing anti-atherosclerotic properties using the Rev-erb receptors and/or the response elements thereof, as well as their effect on apo C-III.
L'invention porte sur l'utilisation de récepteurs de la famille Rev-erb pour le criblage de substances servant au traitement des troubles du métabolisme des lipides liés à l'apolipoprotéine C-III, plus particulièrement sur des procédés de criblage de substances servant au traitement desdits troubles, et sur l'utilisation des substances ainsi identifiées pour la préparation de compositions thérapeutiques servant au traitement desdits troubles. L'invention porte en outre sur des essais de criblage pour la caractérisation, la justification et la revendication du mécanisme d'action de substances anti-athérosclérotiques à l'aide de récepteurs Rev-erb et/ou de leurs éléments de réponse, ainsi que sur leurs effets sur l'apo C-III.
Bonhomme Yves
Raspe Eric
Fetherstonhaugh & Co.
Merck Patent Gesellschaft Mit Beschraenkter Haftung
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