Use of recombinant human uteroglobin in treatment of...

A - Human Necessities – 61 – K

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A61K 38/17 (2006.01) C07K 14/46 (2006.01) C07K 14/47 (2006.01) C07K 17/00 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2338299

Compositions and methods for preventing or treating primary cancer cell growth and tumor metastasis, as well as stimulation of hematopoiesis are described and claimed. The present invention also relates to methods of treating cancer and uteroglobin receptor-related conditions by targeting a uteroglobin receptor with recombinant human uteroglobin (rhUG). Also disclosed and claimed are methods of purifying a uteroglobin receptor and methods of using such receptor(s) to identify uteroglobin structural analogs and UG-receptor ligands.

La présente invention porte sur des compositions et des procédés qu'on utilise pour prévenir ou traiter la croissance de cellules de cancer primitif et la métastase tumorale, ainsi que pour stimuler l'hématopoïèse. On décrit égaleemtn des procédés utiles pour traiter le cancer et les états liés au récepteur d'utéroglobine qui consistent à cibler un récepteur d'utéroglobine avec de l'utéroglobine humaine de recombinaison (rhUG) ; des procédés de purification d'un récepteur d'utéroglobine et des procédés d'utilisation de ce/ces récepteurs pour identifier les analogues structurels d'utéroglobine et les ligands du récepteur UG.

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