C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/09 (2006.01) A61K 38/00 (2006.01) A61P 1/00 (2006.01) A61P 3/04 (2006.01) C07K 14/435 (2006.01) C07K 14/705 (2006.01) C12Q 1/02 (2006.01) G01N 33/15 (2006.01)
Patent
CA 2555469
By intracerebroventricularly administering relaxin-3 binding to SALPR to rats and observing feed intake, body weight, fat amount, etc. of the animals after the administration, it is found out that relaxin-3 has useful effects of promoting food intake, promoting body weight gain and causing obesity. Thus, it is possible to provide a polypeptide having useful effects of promoting food intake, promoting body weight gain and causing obesity; a remedy for diseases containing this polypeptide; a method of screening a compound, a substance or a salt thereof activating or inhibiting a receptor of the polypeptide; a screening kit therefor; and a food intake regulating agent, a remedy for obesity, a remedy for diabetes and so on containing a substance inhibiting the expression of the polypeptide, etc.
En administrant de façon intracérébroventriculaire à des rats de la relaxine-3 se liant au récepteur SALPR et en observant la prise de nourriture, la masse corporelle, la quantité de graisse, etc. des animaux après l'administration, on trouve que la relaxine-3 a des effets utiles consistant à favoriser la prise de nourriture, favoriser le gain de masse corporelle et provoquer l'obésité. Donc, il est possible de fournir un polypeptide ayant des effets utiles consistant à favoriser la prise de nourriture, favoriser le gain de masse corporelle et provoquer l'obésité ; un remède pour des maladies contenant ce polypeptide ; un procédé de test de sélection d'un composé, d'une substance ou d'un sel de celui activant ou inhibant un récepteur du polypeptide ; un kit de test de sélection pour cela ; et un agent de régulation de la prise de nourriture, un remède pour l'obésité, un remède pour les diabètes et ainsi de suite contenant une substance inhibant l'expression du polypeptide, etc.
Arai Tohru
Harada Kokichi
Hida Takayuki
Kosasa Michiko
Sawai Toru
Eisai R. & D. Management Co. Ltd.
Smart & Biggar
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