Use of relaxin to increase arterial compliance

A - Human Necessities – 61 – K

Patent

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A61K 38/17 (2006.01)

Patent

CA 2559745

The present invention provides methods for increasing arterial compliance. The methods generally involve administering to an individual in need thereof an effective amount of relaxin. The present invention further provides methods of increasing arterial compliance in individuals who have Type 1 or Type 2 diabetes. The present invention further provides methods of increasing arterial compliance in perimenopausal, menopausal, and post-menopausal women. The present invention further provides methods of increasing arterial compliance in individuals who have or who are at risk of developing age- associated arterial stiffness.

L'invention concerne des procédés d'augmentation de la compliance artérielle. Ces procédés consistent généralement à administrer à un sujet une dose efficace de relaxine. Par ailleurs, l'invention concerne des procédés d'augmentation de la compliance artérielle chez des sujets atteints de diabète de type 1 ou de diabète de type 2. De plus, l'invention concerne des méthodes d'augmentation de la compliance artérielle chez la femme en période de périménopause, de ménopause, et de post-ménopause. L'invention concerne enfin des procédés d'augmentation de la compliance artérielle chez des sujets souffrant ou susceptibles de souffrir de la rigidité artérielle due à l'âge.

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