Use of resolvins to treat gastrointestinal diseases

Details Use of resolvins to treat gastrointestinal diseases Use of resolvins to treat gastrointestinal diseases

A - Human Necessities

61

K

A61K 31/202 (2006.01) A61K 31/232 (2006.01) A61P 1/00 (2006.01)

Patent

CA 2594310

The present invention relates to the use of therapeutic agents, termed resolvins, generated from the interaction between a dietary omega-3 polyunsaturated fatty acid (PUFA) such as eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) , oxygenases and the analgesic aspirin (ASA) . These compounds are useful therapeutic di- and tri-hydroxy derivatives of EPA or DHA (resolvins of the E series and D series) that diminish, prevent, or eliminate gastrointestinal conditions, for example, such as colitis. The present invention also provides methods of use, methods of preparation, and packaged pharmaceuticals for use as medicaments for the compounds disclosed throughout the specification.

D'une manière générale, agents thérapeutiques isolés, appelés résolvines, issus de l'interaction des substances suivantes : acide gras oméga 3 polyinsaturé alimentaire du type acide éicosapentanoïque ou docosahexaénoïque, oxygénases, et aspirine analgésique. De façon surprenante, l'isolation soigneuse de composés issus de cette interaction dans un environnement approprié, donne des dérivés dihydroxy et trihydroxy de composés contenant les deux acides susmentionnés, à propriétés structurelles et physiologiques uniques. On décrit donc de nombreux dérivés de ce type, utiles sur le plan thérapeutique (résolvines de série E et D), qui atténuent, préviennent ou traitent les affections gastro-intestinales, par exemple du type colite. On décrit enfin des procédés d'utilisation, des procédés d'élaboration et des produits pharmaceutiques conditionnés destinés à être utilisés comme médicaments, correspondant aux composés considérés.

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