A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/538 (2006.01) A61P 1/00 (2006.01) A61P 31/04 (2006.01)
Patent
CA 2730274
Methods for treating bacterial infections in the colon, and colonic disorders caused by bacterial infection, using a poorly absorbable form of Rifalazil, are described. Compositions for oral administration, and colonic delivery, of a non- micro-granulated Rifalazil formulation, are also described. Rifalazil is delivered in a form which is poorly absorbed in the gut after oral dosing, and the vast majority of the orally-dosed Rifalazil is not absorbed in the gut. Accordingly, the antibacterial potency in the colonic flora will be enhanced, while absorption and systemic circulation will be reduced, thus reducing potential adverse events.
La présente invention concerne des méthodes de traitement dinfections bactériennes dans le côlon, et de pathologies du côlon provoquées par linfection bactérienne, à laide dune forme faiblement absorbable de Rifalazil. Linvention concerne également des compositions pour administration par voie orale, et administration au côlon, dune préparation de Rifalazil sous forme autre quen microgranules. Le Rifalazil est administré sous une forme qui est faiblement absorbée dans lintestin après administration par voie orale, et la grande majorité du Rifalazil administrée par voie orale nest pas absorbée dans lintestin. En conséquence, la puissance antibactérienne dans la flore du côlon sera augmentée, tandis que labsorption et la circulation systémique seront réduites, réduisant ainsi les éventuels évènements indésirables.
Activbiotics Pharma Llc
Ridout & Maybee Llp
LandOfFree
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